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Do you DISlike the way the Sheldon character on the TV show Big Bang Theory is written? If YES, then STOP. You will probably not like the book. If NO (i.e., you like the Sheldon character), then continue. Do you have strong opinions about how a character with Asperger's should behave? If YES, then STOP. I've read some reviews by people who felt that the protagonist, Don Tillman, is unbelievable because he does things and responds to things in ways that someone with Asperger's wouldn't do. (I don't want to say what those things are, because it could be spoiler-y.) If NO, then continue. (I do want to note that it's never stated explicitly that Don has Asperger's. Certainly he is lacking in social skills, has everything in his life organized and analyzed for maximum efficiency, and emotions are troublesome for him. But I don't think there is some kind of pattern book that people with Asperger's have to follow. I just looked at Don as an individual, and went with the flow of the book.) Do you enjoy quirky, whimsical humor and romantic comedy? If NO, then STOP. If yes, then continue to the "Look Inside" feature on Amazon's product page, go to Chapter 2 and read the description of Don's talk "Genetic Precursors to Autism Spectrum Disorders." Just that couple of pages should tell you all you need to know, finally, about whether this will be a good reading choice for you. I got a big kick out of the book. It's just a bouncy, character-driven story, and a feel-good romantic comedy. But NOT chick lit; my husband thought it was one of the most entertaining books he's read in quite awhile. ( Amazon customer)