Principles of CNS Drug Development

This title acts as a primer, giving students and newcomers to thefield an opportunity to learn about the breadth of the CNS drugdiscovery. The book outlines the core processes in drug discoveryand development for CNS disorders, from evaluating drugs fordesirable efficacy, safety and pharmacokinetic features inpreclinical (using in vitro and in vivo models) andclinical experimentation to identifying future drug targets.Containing up-to-date experimental evidence and detailing the mainimpediments in the pipeline of CNS drug discovery and development,this is a key reference for those involved in all stages of CNSdrug discovery. Key Features: * Discusses in detail the key stages of CNS drug discovery,outlining the particular requirements and obstacles for CNSdrugs * Addresses safety concerns and future drug targets * Provides succinct background information about the major CNSdiseases * Examples of specific drugs are used throughout to describe thedevelopment of a new drug from conception to clinical use andpost-market surveillance * Primary reasons for drug failure are given for each stage