Metal-Based Neurodegeneration

Neurodegenerative diseases of the human brain appear in variousforms, resulting in disorders of movement and coordination,cognitive deterioration and psychiatric disturbances. Many of thekey factors leading to neurodegenerative diseases are similar,including the dysfunction of metal ion homeostasis, redox-activemetal ions generating oxidative stress, and intracellular inclusionbodies. Metal-based Neurodegeneration presents a detailed surveyof the molecular origins of neurodegenerative diseases. Eachchapter is dedicated to a specific disease, presenting the latestscientific findings, including details of their biochemicalactors (proteins or peptides), their normal and pathologicalconformations, and a description of the diseases characteristics,with an emphasis on the role of metal-induced oxidative stress,which can result in the production of intracellular aggregates oftarget proteins and peptides. Topics covered include: * Brain function, physiology and the blood-brain barrier * Immune system and neuroinflammation * Aging and mild cognitive impairment, MCI * Parkinson's Disease * Alzheimer's Disease * Creutzfelt-Jakob and related prion diseases * Alcoholic Brain Damage * Therapeutic strategies to combat the onset and progression ofneurological diseases This extensively updated, full colour, second edition ofMetal-based Neurodegeneration is an essential text forresearch scientists and clinicians working in gerontology,neuropathology, neurochemistry, and metalloprotein mechanisms.